extract • Contains berberine, a bioactive ingredient that inhibits attachment of non-beneficial bacteria to the gastric mucosa • Helps maintain electrolyte and water balance in the gastrointestinal tract • Enhances absorption of sodium and water • Promotes proper intestinal epithelial tight junction formation • Supports intestinal motility • Aids digestion and relieves digestive disturbances • Made from natural and herbal ingredients Berberis Formula is a powerful blend of barberry, goldenseal, and Oregon grape extracts that have been traditionally used for maintaining gastrointestinal health. The key ingredient in these extracts is berberine, which has been extensively researched and proven to have numerous benefits for the digestive system. One of the main ways in which berberine helps maintain gastrointestinal health is by inhibiting the attachment of non-beneficial bacteria to the gastric mucosa. This helps prevent the colonization of harmful bacteria and promotes a healthy balance of gut flora. Berberine also plays a crucial role in the transport of ions and water across intestinal epithelial cells. It increases the expression of the Na+; H+ exchanger and aquaporin, which are responsible for enhancing the absorption of sodium and water, respectively. This helps maintain the balance between electrolytes and water in the gastrointestinal tract. Additionally, berberine promotes the proper formation of tight junctions in intestinal epithelial cells. These tight junctions act as a barrier, preventing the entry of harmful substances into the bloodstream and promoting appropriate gastrointestinal barrier function. Another benefit of berberine is its ability to support intestinal motility. During low contractile states, berberine stimulates the jejunum through the activation of muscarinic receptors, which helps improve intestinal movements. Traditionally, the herbal ingredients in Berberis Formula have been used as bitters to aid digestion and relieve digestive disturbances. This product includes not only berberine but also goldenseal root extract, barberry root and stem extract, barberry root bark, Oregon grape root extract, and Oregon grape root extract. These natural and herbal ingredients work together synergistically to provide comprehensive support for gastrointestinal health. Berberis Formula is a safe and effective option for individuals looking to maintain a healthy digestive system.